Optimal Dose of Hypertonic Saline/Dextran in Hemorrhaged Swine
Abstract
Background: Hypertonic saline/dextran (HSD) fluid resuscitation has been demonstrated to be effective in alleviating the adverse effects of hemorrhagic hypo- tension. The optimal dose of HSD has not been defined. Methods: The comparative effectiveness of various dosages of HSD for the treatment of severe hemorrhage was investigated in conscious swine bled 46 mL/kg over 15 minutes, a lethal procedure. Five minutes after the completion of hemorrhage, animals were treated with 1, 2, 4, or 11.5 mL/kg HSD and observed over the next 96 hours. Results: The 11.5-mL dose resulted in 100% survival, which was statistically superior to the 1- and 2-mL doses but not the 4-mL dose. Survival incidences with 4, 2, and 1 mL/kg were 83%, 64%, and 13%, respectively. Conclusion: In terms of survival time, the 11.5- and 4-mL/kg doses were not significantly different. Therefore, optimum resuscitative effectiveness of HSD is achieved within the dose range of 4 to 11.5 mL/kg.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA628322
Entities
People
- Charles E Wade
- J. J. Grady
- Michael A. Dubick
Organizations
- United States Army Institute of Surgical Research