High-Frequency Percussive Ventilation and Low Tidal Volume Ventilation in Burns: A Randomized Controlled Trial

Abstract

Objectives: In select burn intensive care units, high-frequency percussive ventilation is preferentially used to provide mechanical ventilation in support of patients with acute lung injury, acute respiratory distress syndrome, and inhalation injury. However, we found an absence of prospective studies comparing high-frequency percussive ventilation with contemporary low-tidal vol- ume ventilation strategies. The purpose of this study was to prospectively compare the two ventilator modalities in a burn intensive care unit setting. Design: Single-center, prospective, randomized, controlled clinical trial, comparing high-frequency percussive ventilation with low-tidal volume ventilation in patients admitted to our burn intensive care unit with respiratory failure. Setting: A 16-bed burn intensive care unit at a tertiary military teaching hospital. Patients: Adult patients greater than 18 yrs of age requiring prolonged ( greater than 24 hrs) mechanical ventilation were admitted to the burn intensive care unit. The study was conducted over a 3-yr period between April 2006 and May 2009. This trial was registered with ClinicalTrials.gov as NCT00351741. Interventions: Subjects were randomly assigned to receive mechanical ventilation through a high-frequency percussive ventilation-based strategy (n = 31) or a low-tidal volume ventilation- based strategy (n = 31). Measurements and Main Results: At baseline, both the high- frequency percussive ventilation group and the low-tidal volume ventilation group had similar demographics to include median age (interquartile range) (28 yrs [23 - 45] vs. 33 yrs [24 - 46], p nonsignificant), percentage of total body surface area burn (34 [20 - 52] vs. 34 [23 - 50], p = nonsignificant), and clinical diagnosis of inhalation injury (39% vs. 35%, p = nonsignificant).

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2010
Accession Number
ADA629414

Entities

People

  • Booker T. King
  • Christopher E. White
  • David G. Bell
  • Evan M. Renz
  • Gerald A. Merrill
  • James Keith Aden
  • Kevin K Chung
  • Mehdi C. Shelhamer
  • Patrick F. Allan
  • Steven Wolf

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Airway Management
  • Blood
  • Brain Injuries
  • Burns
  • Frequency
  • Health Services
  • Intensive Care Units
  • Lung Diseases
  • Medical Personnel
  • Respiratory Physiological Phenomena
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Marine Mammal Biology
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.