Early Initial Antibiotics and Debridement Independently Reduce Infection in an Open Fracture Model

Abstract

Most animal studies indicate that early irrigation and debridement reduce infection after open fracture. Unfortunately, these studies often do not involve antibiotics. Clinical studies indicate that the timing of initial debridement does not affect the rate of infection but these studies are observational and fraught with confounding variables. The purpose of this study was to control these variables using an animal model incorporating systemic antibiotics and surgical treatment.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2012
Accession Number
ADA629590

Entities

People

  • C. K. Murray
  • J. C. Wenke
  • J. G. Penn-barwell

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Bone Fractures
  • Debridement
  • Health Services
  • Infection
  • Rodents
  • Soft Tissues
  • Statistical Analysis
  • Surgery
  • United States
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Medicine

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