Development and Characterization of a Scalable Microperforated Device Capable of Long-Term Zero Order Drug Release
Abstract
A drug delivery system that consists of micro-perforated polyimide microtubes was developed and characterized. Two groups of polyimide tubes were used. One set consisted of microtubes (I.D.=125 micro(m) with 32.9 + or - 1.7 micro(m) size holes. The second set consisted of larger tubes (I.D.=1000 micro(m) with 362 542 micro(m) holes. The number of holes was varied between 1 and 3. The small tubes were loaded with crystal violet (CV) and ethinyl estradiol (EE) and the drug release studies were performed in 0.01 M phosphate buffered saline (PBS) (pH 7.1 7.4) at 37.0 1.0 C for upto 4 weeks. The large tubes were loaded with CV and the drug release was studied in vitro in PBS and also ex vivo in rabbits vitreous humor. Linear release rates with R 2 greater than 0.9900 were obtained for all groups with CV and EE. Release rates of 7.8 2.5, 16.2 + or - 5.5, and 22.5 6.0 ng/day for CV and 30.1 5.8 ng/ day for EE were obtained for small tubes. For large tubes, a release rate of 10.8 + or - 4.1, 15.8 + or - 4.8 and 22.1 + or - 6.7 micro(mg)/day was observed in vitro in PBS and a release rate of 5.8 + or - 1.8 micro(m)g/day was observed ex vivo in vitreous humor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 29, 2010
- Accession Number
- ADA630198
Entities
People
- Ashish Rastogi
- Paul S. Ho
- Phillip D. Bowman
- Salomon Stavchansky
- Zhiquan Luo
- Zuojie Wu
Organizations
- United States Army Institute of Surgical Research