Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPA) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE)

Abstract

A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA.

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Document Details

Document Type
Technical Report
Publication Date
Jun 11, 2010
Accession Number
ADA630199

Entities

People

  • Gwendolyn A. Marriner
  • John Yang
  • Phillip D. Bowman
  • Salomon Stavchansky
  • Sean M. Kerwin
  • Xinyu Wang

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Acids
  • Amides
  • Analogs
  • Chemical Synthesis
  • Chemistry
  • Chromatography
  • Column Chromatography
  • Culture Media
  • Endothelial Cells
  • Hydrogen
  • Magnetic Resonance
  • Mass Spectrometry
  • Nuclear Magnetic Resonance
  • Oxidative Stress
  • Rocket Oxidizers
  • Statistical Analysis
  • Vascular Diseases

Fields of Study

  • Chemistry

Readers

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