Clot-Inducing Minerals Versus Plasma Protein Dressing for Topical Treatment of External Bleeding in the Presence of Coagulopathy
Abstract
Background: Previous studies identified WoundStat (WS, smectite) and Combat Gauze (CG, kaolin-coated gauze) as the most effective available agents for controlling arterial bleeding with potential utility in casualty care. Tissue sealant properties of WS suggested its potential advantage over clot-promoting CG for treating coagulopathic bleeding. This study compared the efficacy of CG and WS with a fibrinogen-based (FAST) dressing to control bleeding in coagulopathic animals. Methods: Coagulopathy was induced in pigs (n = 55, 35 kg) by approximately 50% isovolemic hemodilution and hypothermia (core temperature, 33 Degrees C + or - 0.5 Degrees C). A 6-mm arteriotomy was made in the femoral artery and free bleeding allowed for 30 seconds. A test agent (n 13-15 per group) or control product (gauze, GZ, n = 12) was applied to the wounds and compressed with a Kerlix gauze for 2 minutes. Fluid resuscitation was given, titrated to a mean arterial pressure of 65 mm Hg. Animals were observed for 180 minutes or until death. Angiography using the computed tomography method was performed on survivors, and local tissues were collected for histology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2010
- Accession Number
- ADA630324
Entities
People
- Bijan Shams Kheirabadi
- Chriselda G. Fedyk
- Dawson Beall
- Irasema B. Terrazas
- J. S. Estep
- James E. Mace
- Krystal K. Valdez
- Lorne H Blackbourne
- Martin J. Macphee
- Michael A. Dubick
Organizations
- United States Army Institute of Surgical Research