Noninvasive In Vivo Monitoring of Cyanide Toxicity and Treatment Using Diffuse Optical Spectroscopy in a Rabbit Model

Abstract

Currently, no reliable noninvasive methods exist for monitoring the severity of in vivo cyanide (CN) toxicity, treatment, and resulting physiological changes. We developed a broadband diffuse optical spectroscopy (DOS) system to measure bulk tissue absorption and scattering, DOS was used to optical monitor CN toxicity, and treatment with sodium nitrite (NaNO2). To perform experiments, the DOS probe was placed on the hind leg of rabbits. A sodium CN was infused intravenously.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
ADA630384

Entities

People

  • Amit Uppal
  • Andrew Tran
  • Andriy I. Batchinsky
  • Bruce J. Tromberg
  • David Mukai
  • Jae Kim
  • Jangwoen Lee
  • Kelly A. Keuter
  • Leopoldo C. Cancio
  • Sari B. Mahon

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Absorption
  • Blood
  • Blood Gases
  • Carbon Monoxide
  • Detection
  • Dielectric Gases
  • Frequency
  • Gases
  • Health Services
  • Hemoglobin
  • Measurement
  • Medical Personnel
  • Military Medicine
  • Oxygenation
  • Scattering
  • Spectroscopy
  • United States

Fields of Study

  • Physics

Readers

  • Organic Chemistry
  • Spectroscopy.
  • Trauma Surgery or Emergency Medicine.