Tulane/Xavier Vaccine Development/Engineering Project

Abstract

The Tulane/Xavier Biodefense Vaccine Development/Engineering project will develop new vaccines against biological threat agents to aid the war-fighter. Through the innovative use of nanotechnology, researchers and engineers from the Tulane University Schools of Medicine and Science & Engineering and the Xavier College of Pharmacy will fabricate nanoparticulate systems that are effective for transdermal and mucosal delivery of life-saving vaccines. One aim of this project will be to compare different nanocarriers for the ability to incorporate biological threat-relevant vaccine antigens and deliver those antigens through the stratum corneum to immune-responsive cells in the epidermis. The specialized assembly of each type of nanocarrier gives each unique properties and different interactions within the lipid channels of the stratum corneum. The use of nanocarriers for vaccine delivery is a platform technology, applicable to delivery of a variety of existing and potential vaccines.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2010
Accession Number
ADA630573

Entities

People

  • John D. Clements

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • Antigen-Presenting Cells
  • Biomedical And Dental Materials
  • Electron Microscopy
  • Emulsions
  • Engineering
  • Epidermis
  • Epithelial Cells
  • Health
  • Health Care
  • Health Services
  • Immunization
  • Infectious Diseases
  • Microscopy
  • Molecular Weight
  • Particle Size
  • Skin
  • Universities

Readers

  • Groundwater Contamination Remediation.
  • Nanocomposite Materials Science
  • Research Science/Academic Research

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech