Molecular Determinants Fundamental to Axon Regeneration After SCI

Abstract

We hypothesize that the ability to grow an axon over CSPGs is intrinsic to adult zebrafish brainstem neurons and entails the expression of a distinct set of genes. This premise will be addressed using in vitro adult zebrafish brainstem cell culture systems and in vivo adult zebrafish spinal cord injury model systems. In cultures, we have observed three distinct populations of brainstem neurons with regard to their response to chondroitin sulfate proteoglycans (CSPG). Some cells attach, extend processes, and remain exclusively associated with CSPG. Other cells attach outside and extend processes into CSPG-rich area.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2011
Accession Number
ADA631184

Entities

People

  • Jeffrey Plunkett

Organizations

  • University of St. Thomas

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Cell Nucleus
  • Cells
  • Central Nervous System
  • Culture Techniques
  • Cultured Cells
  • Department Of Defense
  • Fish
  • Genetics
  • Histological Techniques
  • Molecules
  • Nervous System
  • Neurons
  • Neurosciences
  • Polysaccharides
  • Regeneration (Physiology)
  • Spinal Cord

Fields of Study

  • Biology

Readers

  • Neuroscience