Complement and Immunoregulation in Tissue Injury

Abstract

Our goal is to ultimately enable the development of novel therapeutic agents and strategies to ameliorate tissue injury in I/R related conditions. Preliminary findings suggested a role for Il-17 & IL-23 axis in ischemia reperfusion injury which we have continued to study. We have shown that by depleting IL-17 and IL-23 tissue injury is alleviated. Our findings unravel the therapeutic role of R-spondin 3 in protecting tissues from damage by preventing endothelial barrier dysfunction and dampening I/R enhanced local inflammatory response. We are now exploring in depth the regulatory mechanisms by which R-spo3 plays its protective role in tissue injury for therapeutic purposes.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2015
Accession Number
ADA631909

Entities

People

  • George Tsokos

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Cells
  • Cardiovascular System
  • Cells
  • Diseases And Disorders
  • Epithelial Cells
  • Hematopoietic Cells
  • Hemorrhage
  • Hemorrhagic Shock
  • Intestines
  • Ischemia
  • Lymphocytes
  • Molecules
  • Mucous Membrane
  • Small Intestine
  • Vascular Diseases

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Systems Analysis and Design