Effectiveness of Local Antibiotic Delivery with Osteoinductive Osteoconductive Bone-graft Substitutes

Abstract

The morbidity associated with open fractures and open fracture treatment is well established. An osteoinductive and osteoconductive bone graft substitute that prevents infection would decrease the number of procedures required to treat contaminated fractures by eliminating the need for surgical removal of cement beads and perhaps autograft harvest. We hypothesized that the combination of tobramycin impregnated calcium sulfate pellets and demineralized bone matrix would prevent the establishment of infection in a contaminated fracture model.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA632541

Entities

People

  • Anthony A. Beardmore
  • Daniel E. Brooks
  • Darryl. B. Thomas
  • Joseph C Wenke

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Bone And Bones
  • Bone Fractures
  • Calcium Compounds
  • Elements
  • Infection
  • Information Operations
  • United States
  • Wound Infections

Readers

  • Trauma Surgery or Emergency Medicine.