Evaluation of Gastric Function in Primates Following the Administration of Agents Which Act at the Kappa Receptor
Abstract
The physiological effects of kappa agonists on gastric function have not been fully elucidated. In the present studies, the effect of kappa receptor agonists (dynorphin(1-13), U50,488H and ketocyclazocine), a putative antagonist of the kappa receptor (MR1452 MS), and a nonspecific opiate antagonist (Naloxone) , on gastric emptying and secretion were evaluated alone and in combination. A marker dilution technique was used to measure, concurrently, gastric fractional emptying rate and secretion in conscious, chair-adapted rhesus monkeys during a fasting period and following the intragastric administration of an 80 ml water load (pH 7.4, 37" C). All values listed as significant had a p value of less than 0.05. The opioid agonists utilized in these studies inhibited gastric emptying. Unlike agonists that are active at mu (morphine) and delta (enkephalins) receptors, selective kappa agonists (dynorphin-(1-13); U50,488H) did not alter acid secretion, while the kappa/mu agonist, ketocyclazocine, significantly decreased it.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1988
- Accession Number
- ADA634917
Entities
People
- Patricia L. Touzeau
Organizations
- Uniformed Services University of the Health Sciences