Raman Spectroscopy of the Interferon-Induced 2',5'-Oligoadenylates
Abstract
Development of cell-free protein synthesis systems in the early 1970's have made possible the elucidation of many complex biochemical processes at the molecular level. Use of these systems has been largely responsible for the insight gained about the mechanism of interferon (IFN) 1 action. Interferons are a family of proteins, many of which share some sequence homology (Lengyel, 1982 and references therein). They occur in a wide variety of vertebrates from fish to man and are important modulators of cell function. Unless they are induced, their concentration is below the level of detection in most organs ani cell culture systems. Human interferons are historically classed into three antigenically distinct types, alpha, beta, ani gamma. Alpha interferons are produced mainly by myeloid cells, beta interferons are produced mainly by solid tissue types such as fibroblasts, and gamma interferons are produced by T-lymphocytes. Alpha and beta interferons can be induced by a variety of agents including certain viruses, certain bacteria and protozoa, and natural or synthetic double stranded RNA (dsRNA) such as poly(I) poly(C) (Lengyel 1982) certain tumor derived or virus transformed cells are also reported to induce a-interferons in antigen, mitogen, or lectin stimulated T lymphocytes and in NK cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 25, 1987
- Accession Number
- ADA635282
Entities
People
- Joseph C. White
Organizations
- Uniformed Services University of the Health Sciences