Development of Novel Therapeutics for Neglected Tropical Disease Leishmaniasis
Abstract
We undertook planning of kick off coordination meeting. A low dose infection model of CL was validated. A large scale synthesis of PEN optimized and in vitro studies were performed revealed that PEN alters parasite lipidome. Further studies were undertaken using synthetic PEN (sPEN) which showed that sPEN is effective in vivo in treatment of L. donovani infection. We have also synthesized ten analogues of PEN were synthesized as well as established synthesis of DNER. Testing of these compounds under way.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- ADA637013
Entities
People
- Abhay R Satoskar
Organizations
- Ohio State University