Development of Extraction Tests for Determining the Bioavailability of Metals in Soil
Abstract
The research conducted under this project is designed to yield a database that establishes whether site- or soil-specific factors affect the bioavailability of target metals from soils. Where the database (from in vivo research) identifies that these types of factors are operating, an additional goal of the research has been to develop simple extraction tests that are inexpensive to perform and that are predictive of metals bioavailability from soil. These tools can then be available to U.S. Department of Defense (DoD) personnel for site-specific evaluation of metals bioavailability from soil at field sites and will result in more accurate exposure and risk estimates that are still protective of human health and the environment. Exposure pathways and receptors of concern were established to target the in vivo research, and focused on three distinct areas: oral bioavailability to humans, dermal bioavailability to humans, and oral bioavailability to wildlife. The project was designed in this manner, because each of these receptor/pathway combinations requires a different approach, due to the differences in the mechanism of absorption and/or differences in risk assessment methods. The research was undertaken in three phases. First, research was conducted to understand which metals are risk drivers at DoD sites. Second, in vivo testing was conducted on soils to understand whether there are site- or soil-specific parameters that control absorption, and if so, to generate a database of information upon which to base development and validation of in vitro approaches to assessing bioavailability. The third phase, conducted once the in vivo data were compiled, involved determining whether in vitro methods for approximating bioavailability can be supported.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA637526
Entities
People
- Michael V. Ruby
- Yvette W. Lowney