4-Amino 2-Nitrotoluene (4A2NT) Oral Approximate Lethal Dose 14-day Range Finding 90-day Subchronic Feeding Studies in Rats, August 1991-November 1993
Abstract
The subchronic study examined the toxicity of 4-Amino 2-Nitroluene (4A2NT) in rats following oral administration in feed for 90 days. Associated with the administration of 4A2NT in rats was testicular hypospermatogenesis (atrophy) a higher incidence of cardiomyopathy, anemia and a high incidence of hecatocellular cytoplasmic vacvolization. A no observed adverse effect level in the 90-day study was not established. The lowest-observed-adverse-effect-level in the 90-day study was 27 mg/kg/day for males and 32 mg/kg/day for females.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1994
- Accession Number
- ADA639936
Entities
People
- Glenn J. Leach
- John T. Houpt
Organizations
- United States Army Medical Command