Thirteen Week Oral Toxicity Study of WR238605 with a Thirteen Week Recovery Period in Dogs. Volume 3
Abstract
This study evaluated the toxicity of WR238605 in dogs following thirteen weeks of daily oral (gavage) administration. A thirteen week recovery period was included for all groups. Dose levels studied were 0 (vehicle control), 0.1, 2.0 and 6.0 mg base/kg/day. The primary toxic effects of WR238605 were seen in the lungs and RBCs. Drug treatment was associated with hemolytic anemia which was supported by reticulocytosis, bone marrow hypercellularity, decrease in bone marrow MJE ratio, splenomegaly, extramedullary hematopoiesis, and hemosiderosis in the liver and spleen. Mild hepatotoxicity as evidenced by hepatocyte necrosis (high dose males) was supported by altered clinical chemistry values. Possibly, secondary to the hematologic alterations, congestion of retinal vessels was seen in one high dose female, which was no longer evident by the end of the recovery period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 11, 1993
- Accession Number
- ADA640033
Entities
People
- Barry S. Levine
- Michael J. Tomlinson
Organizations
- University of Illinois at Chicago