Protective and Therapeutic Agents for War Gases - BAL Derivatives and Analogs
Abstract
A synthesis of compounds containing the vicinal dithiol structure in a wide variety of structural arrangements is given. Homologs were prepared so that structure and efficacy could be further correlated. About sixty analogs and derivatives of BAL were prepared and submitted for therapeutic and toxicity studies; 2,3-dimercaptopropyl ethyl ether was found to be the most effective agent for arsine therapy, surpassing all other compounds tested. A novel approach to the problems of dithiol synthesis has involved the preparation of derivatives of BAL or its analogs in which existing thiol groups were converted to new, labile structures. A new synthetic technique was applied to the preparation of dimercaptotetrahydrothiophene-1-dioxide and 2,3-dimercaptopropionic acid. Dithioglycidol was condensed with aniline and methylaniline, by opening of the ethylene sulfide ring, to yield monomeric dithiols.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 22, 1945
- Accession Number
- ADA801584
Entities
People
- A. A. Pavlic
- F. K. Singaigo
- P. L. Salzberg
- W. A. Lazier