Protective and Therapeutic Agents for War Gases: Therapeutic Agents for Mustard and Nitrogen Mustards 2
Abstract
Work was done on the preparation of derivatives and analogues of o-aminobenzenethiol which bear substituents calculated to reduce the toxicity of the parent compound without loss of therapeutic efficiency. Fourteen candidate compounds were synthesized to CMR for evaluation; the majority of these were difficultly accessible derivatives of o-aminobenzenethiol. Of the candidates submitted, 4-amino-3-mercaptobenzoic acid and its ethyl ester hydrochloride were reported to have decontaminating powers for splashes of mustard gas and the nitrogen mustards in the eyes of test animals (rabbits). The synthesis of appropriately substituted aminobenzenethiols from the corresponding 2-aminobenzothiazoles has been shown to be a valuable synthetic tool.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 10, 1946
- Accession Number
- ADA801585
Entities
People
- A. A. Pavlic
- B. W. Howk
- P. L. Salzber
- W. A. Lazier