Study of African Trypanosomiasis.
Abstract
Calves have been immunized for varying periods of time by passive transfer of immune T4 rhodesiense serum. Immunized animals and controls were challenged with 1 x 10 trypanosomes from infected rats. Those immunized failed to develop demonstrable infection whereas controls did. In Lambwe Valley (western Kenya by Lake Victoria) isolates of T. rhodesiense were collected from human cases and injected into rats. Parasites from human cases in Ethiopia and Tanzania as well as from 83 cattle (T. brucei) were all tested by neutralization (Solytes) with antisera collected from bovines which had undergone longterm infection with various isolates. All four isolates from Lambwe Valley appear to be antigenically similar since antiserum to one neutralized all others within the limits of our tests. When isolates from T. brucei from cattle were tested, the antiserum showed a strong effect against three of the nine isolates indicating that these cattle were infected with the same strain as the four humans. New investigations of the feasibility of practical artificial immunization by the use of irradiated trypanosomes and on the pathophysiological process occurring in trypanosomiasis in cattle are underway. (Author).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1974
- Accession Number
- ADA954875
Entities
People
- I. Muriithi
Organizations
- United States Army Medical Research Unit-Kenya