Formation of Debri (Platelet, White Cell, Fibrin Aggregates) in Stored Blood: Physiological Significance and Removal by Filtration.
Abstract
Blood stored at 4 degrees C. in ACD solution has been shown to develop microaggregates composed primarily of platelets and fibrin. This debris in transfused blood has been shown to produce changes in pulmonary hemodynamics in animals and has been implicated in the pathogenesis of post-traumatic pulmonary insufficiency in man. The present studies were undertaken to more clearly define the mechanism by which these microaggregates are formed. It is directed primarily at studying evolutionary changes in platelet function and fibrinogen composition of stored human blood.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1973
- Accession Number
- ADA954917
Entities
People
- Jack J. McNamara
Organizations
- The Queen's Medical Center