Human Platelet Senescence.
Abstract
Large-heavy platelets, or megathomnocytes, when compared to small-light platelets have been shown to be more active metabolically and functionally; more resistant to osmotic stress; and kinetically young, as determined via platlet precursor labelling studies with Se75-selenomethionine and by kinetic studies with a thrombopoietic stimulus. Recognition of megathrombocytes has been shown to be useful clinically. Their enumeration can be helpful in the prediction of megakaryocyte number (for turnover), as well as a compensated thrombocytolytic state. Recent published work has been directed towards an attempt to determine the critical rate-limiting steps controlling in vitro platelet senescenced. Work has been directed towards the kinetics of megathrombocyte (large young platelet) production. It was also found that plasma from chronically bled animals as capable of inducing thrombocytosis and megathrombocytosis when injected into recipient animals - indicating the presence of a humoral factor or hormone.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 30, 1973
- Accession Number
- ADA955155
Entities
People
- Simon Karpatkin
Organizations
- NYU Langone Health