A Study of Tolerance and Safety of a Combination of Anti-Malarial Drugs in Young Adult Males.
Abstract
The purpose of this study was to determine the safety for extended use in humans of 4,4'diformamidodiphenylsulfone (DFD) an antimalarial drug proven effective if given once a week with chloroquine-primaquine. Currently, the usual treatment for malaria utilizes another sulfone, diaminodiphenylsulfone (DDS) in combination with chloroquine-primaquine. However, to maintain effectiveness, DDS must be given daily. DFD, requiring only weekly administration, offers an obvious advantage. It is concluded that long-term (up to 52 weeks) administration of DFD to male prison volunteers had no serious untoward effects. There is no build-up of the drug as a result of a single weekly oral dose of 800 mg.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 04, 1972
- Accession Number
- ADA955165
Entities
People
- Charles F. Weiss
Organizations
- University of Florida