Infectious Multiple Drug Resistance in the Enterobacteriaceae
Abstract
The structural gene for plasmid-mediated ampicillin resistance resides upon a 3.2 x 10 to the 6th power dalton transposable sequence, TnA, flanked by short inverted repeated sequences which accompany its insertion. Over the past several years plasmids mediating resistance to ampicillin and other penicillin derivatives as well as tetracycline, kanamycin and chloramphenicol have been identified in strains of Haemophilus influenzae. These resistance determinants are identical to the transposable antibiotic resistance genes of enteric species. During the past year penicillinase producing gonococci have been identified in U.S. Military personnel returning from duty in the Far East. The penicillin resistant gonococcal isolates carry a plasmid which carries about 40% of the TnA sequence. Thus, the recent findings in both H. influenzae and N. gonorrhoeae suggest that direct or indirect extension of the resistance pool of enteric bacteria to other heretofore universally susceptible gram negative bacteria.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1976
- Accession Number
- ADB016727
Entities
People
- Stanley Falkow
Organizations
- University of Washington