The Synthesis and Study of New Ribavirin Derivatives and Related Nucleoside Azole Carboxamides as Agents Active against RNA Viruses

Abstract

To examine the structural parameters necessary for antiviral efficacy of certain azole carboxamide nucleosides and nucleotides, several imidazole, pyrazole and 1,2,4-triazole carboxamide nucleosides have been synthesized. New methods have been developed to prepare Ribavirin derivatives. All the compounds prepared during the subject contract have been tested at the U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick. Ribavirin 3',5'-cyclic phosphate (BJ-58536) exhibited superior in vivo activity against Venezuelan equine encephalitis (VEE) over that of ribavirin. In preliminary results on day 20 at 25 mg/kg/day of BJ-58536 there were 20 out of 20 survivors in the VEE-infected mice compared to 8 out of 20 survivors in the control.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1980
Accession Number
ADB055800

Entities

People

  • Ganapathi R. Revankar
  • Roland K. Robins

Organizations

  • Brigham Young University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Azoles
  • Biomedical Research
  • Diseases And Disorders
  • Equine Encephalitis
  • Infectious Diseases
  • Nucleosides
  • Parasitic Diseases
  • Rna Viruses
  • Test And Evaluation
  • Virus Diseases
  • Viruses
  • Zoonoses

Fields of Study

  • Chemistry

Readers

  • Parasitology and Pharmacology of Malaria.
  • Virology (or Medical Virology).