Preformulation Studies on Antimalarials

Abstract

This annual report contains: (1) a description of liposome preparation techniques; (2) methods for evaluating liposome entrapment; (3) uv spectral data on WR6026.2HCl; (4) tonicity results on aqueous solutions of WR6026.2HCl and WR2975 phosphate (primaquine); (5) entrapment results for WR6026.2HCl in various liposome formulations; (6) entrapment results for WR2975 phosphate in liposomes; (7) recommendations for biological evaluation of liposomes; (8) solubility studies on WR6026.2HCl; (9) stability studies in WR6026.2HCl in various aqueous media; (10) cobalt salt studies; (11) coprecipitate studies of WR171,669.HCl with polyvinylpyrrolidone (PVP); (12) production information on WR171, 669.HCl (Halofantrine hydrochloride) capsules; and (13) quality control test results on the capsules produced.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1981
Accession Number
ADB081441

Entities

People

  • Douglas R. Flanagan
  • John L. Lach
  • Lloyd E. Matheson Jr.

Organizations

  • University of Iowa

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Antimalarials
  • Chlorides
  • Dispersions
  • Dosage Forms
  • Drying
  • Health Services
  • High Pressure
  • Liquid Chromatography
  • Manufacturing
  • Materials
  • Mixing
  • Plastic Explosives
  • Primaquine
  • Solubility
  • Transition Temperature
  • Vitamin E

Fields of Study

  • Chemistry

Readers

  • Analytical Chemistry
  • Parasitology and Pharmacology of Malaria.
  • Systems Analysis and Design