Preformulation Studies of Selected Pretreatment and Therapeutic Compounds

Abstract

This annual report represents preformulation and formulation and production projects conducted in the fourth year of this contract on the following drugs: WR6026-2HC1; WR638; WR180,409-H3PO4; WR142,490-HC1; WR171,669-HC1; and Formycin B,5' Monophosphate. This work consists of the physicochemical characterization of WR6026-2HC1 including stability studies; formulation and production of WR638 capsules; formulation and production of WR180,409-H3PO4 tablets and matching placebos; coating of WR142,490-HC1 tablets and formulation and production of matching placebos; the preparation of capsules containing 14C labelled WR171,669-HC1 with polyvinylpyrrolidone; and the development of liposomes containing formycin B,5' monophosphate.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1983
Accession Number
ADB094143

Entities

People

  • Douglas R. Flanagan
  • John L. Lach
  • Lloyd E. Matheson Jr.

Organizations

  • University of Iowa

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Aqueous Solutions
  • Biomedical Research
  • Chlorides
  • Diffraction
  • Dosage Forms
  • Films
  • Heavy Metals
  • Materials
  • Mixing
  • Mixtures
  • Packaging
  • Particle Size
  • Particles
  • Polymers
  • Spectra
  • United States

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