Investigations Concerning Hydrolysis and Stabilization of Antiradiation Compounds

Abstract

This report covers studies conducted on S-2-(3-aminopropylamino) ethylphosphorothioic acid, WR 2721, over the period January 16, 1982 through January 15, 1983. The most significant results obtained during this report period are the following: A blood assay method has been developed for WR 2721 over the range of < or = 1 microgram/mL to >1000 micrograms/mL. The assay method has been used successfully in two preliminary dosing experiments with beagle dogs. WR 2721 appears to have an initial short half-life in plasma. An HPLC blood assay method for WR 1065 and WR 33278 appears feasible based upon early results. WR 2721 can be reproducibly encapsulated to give good protection of the drug against acid hydrolysis and rapid release at pH 7.5.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1982
Accession Number
ADB094912

Entities

People

  • C. W. Lew
  • D. J. Mangold
  • E. M. Gause
  • E. P. Mcgovern
  • N. F. Swynnerton

Organizations

  • Southwest Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acids
  • Alcohols
  • Alkanes
  • Amines
  • Blood
  • Buffers (Chemistry)
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Detectors
  • Dosage Forms
  • Encapsulation
  • Fatty Acids
  • Materials
  • Microcapsules
  • Stearic Acid
  • Veins

Readers

  • Immunology
  • Neurotoxicology
  • Organic Chemistry