Structure-Activity Relationships of Agents Modifying Cholinergic Transmissions.
Abstract
Structure activity relationship studies of hemicholinium (HC-3) analogs are directed toward better understanding both the spatial aspect of the receptor and interatomic distances between the 2 cationic heads. Two series of compounds involving 4,4' biphenyl and trans-cyclohexyl derivatives are being investigated and both series are potent inhibitors of acetylcholine synthesis. One compound, N-methyl 4-methyl piperdine derivative in the biphenyl series, is a very active inhibitor of ACh synthesis. The tertiary amine analog is an active inhibitor of synthesis of acetylcholine. It is much less active than the quaternary derivative.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1984
- Accession Number
- ADB103280
Entities
People
- J. G. Cannon
- J. P. Long
- R. K. Bhatnagar
Organizations
- University of Iowa