Controlled-Release Personal Use Arthropod Repellent Formulation
Abstract
BIOTEK, Inc. has developed an arthropod repellent formulation containing N,N,-diethyl-m-toluamide (Deet) for topical application to exposed skin which will provide protection for a duration of 12 hours. This has been achieved by formulating the active ingredient, Deet, with a proprietary blend of silica gel, a lotion base, and alcohol. The formulation is non-toxic, is cosmetically acceptable, is more compatible with military materials than the current in-use formulation, and complies with EPA specifications. In vitro testing of our formulation in a Reifenrath permeation/evaporation cell using weanling pig skin shows an evaporation rate greater than the minimum effective evaporation rate described by the Request for Proposal for a period of 22 hours. Under standard clinical test conditions of moderate temperature and humidity, the formulation provided 100% protection against Aedes aegypti mosquitoes for at least 12 hours, at an applied formulation dose of 2 mg per square centimeter. It is expected that protection may be maintained beyond 12 hours since complete protection was evident at 12 hours when testing was concluded.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 25, 1985
- Accession Number
- ADB105108
Entities
People
- E. S. Nuwayser
- J. A. Mahoney
- M. H. Gay
- P. D. Blaskovich