The Screening and Evaluation of Experimental Antiparasitic Drugs.
Abstract
These investigations included 2 antimalarial drug screens, and 2 African trypanosome drug screens, both of which are In vivo tests in rodent infections. The 2 antimalarial screens were: a primary blood schizonticidal test using Plasmodium berghei and a secondary drug screening system using rodent malaria and Anopheles stephensi mosquitoes. The 2 Africian trypanosome systems included a primary antitrypomastigote screen and a secondary drug-resistant screen, both using Trypanosoma rhodesiense. In the primary antimalarial blood schizonticidal test in 1,500 compounds were tested with 74 exhibiting activity. In the secondary screening system halofantrine, homoharringtonine, and quinghaosu were tested in a 6-day suppressive test. Seven tests were done to detect synergistic activity. Four drug-resistant lines have been passed without drug pressure for 54 months with their resistance remaining stable. Keywords: African trypanosomiasis tests; Pentamidines; Melarsoprols, Resistance(Biology).
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1986
- Accession Number
- ADB108556
Entities
People
- Arba L. Ager Jr.
Organizations
- University of Miami