Toxicologic Studies for Investigational New Drugs.
Abstract
This annual report presents the results of six toxicological studies on two investigational new drugs completed from 1 May 1982 through 31 May 1983. The general purpose of this program is to provide preclinical animal safety data on candidate antiparasitic test materials. The testing program provides acute and subacute toxicity data to meet requirements of the Food and Drug Administration and, specifically, to support data requirements for Investigational New Drug Applications for Phase I and early Phase II clinical studies. Two drugs (WR 141,669.HC1 and WR 228,258.2HC1) have been tested for Walter Reed Army Institute of Research. WR 171,669.HC1 was evaluated using the following tests: acute subcutaneous toxicity study in mice and toxicity reversal study in rats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1983
- Accession Number
- ADB108614
Entities
People
- Frederick E. Reno
- Janet A. Trutter
- Raymond H. Cox
- Richard W. Voelker