Investigations Concerning Hydrolysis and Stabilization of Antiradiation Compounds.
Abstract
This report contains the results of the following studies: 1) Production or ethiofos microspheres/tablets and enteric-coated microcapsules/tablets for use as oral dosage forms. In vitro evaluation of the microsphere/microcapsule/tablet formulations for specific content and release of ethiofos. Development of analytical methodology for the determination of the following: Total convertible drug (e.g., ethiofos, WR-33278 and mixed disulfide conjugates, including cysteamine - WR-1065) to WR-1065; Cysteamine in plasma and urine; Equivalent ethiofis (14 C)-ethiofos in whole blood, plasma, urine and feces. Determination of hydrolysis rate constant for WR-3689. Pharmacokinetic assessment of intravenous, intraperitoneal and duodenal administration of ethiofos to the rhesus monkey.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 28, 1986
- Accession Number
- ADB109038
Entities
People
- B. K. Huelle
- C. W. Lew
- D. J. Mangold
- M. A. Miller
- N. F. Swynnerton
Organizations
- Southwest Research Institute