Synthesis of Potential Trypanocides.
Abstract
This report describes research conducted to identify new chemical compounds which could be evaluated as trypanocidal agents. An extensive series of quaternary heteroaromatic salts has been synthesized by chemical methods which are documented in the reports. Many of the compounds exhibit activity in in vivo screens against Trypanosome rhodesiense in mice. The most active compounds are derivatives of the imidazo pyridinium ring system, although several related ring systems exhibit substantial activity. The most potent compounds are guanylhydrazone and N-substituted guanylhydrazones. Several such compounds exceed previously known trypanocidal drugs in level of activity. Three compounds are designed as potential candidates for preclinical and toxicological investigation. Keywords: Trypanosomiasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1986
- Accession Number
- ADB109043
Entities
People
- Richard J. Sundberg
Organizations
- University of Virginia