Antiradiation Drugs without Amino Groups.
Abstract
In synthetic work aimed at the synthesis of novel antiradiation agents that contain no nitrogen, 21 submissions have been made for biological testing. These included representative alkanesulfinates terminated by a variety of polar, non-polar, and sulfur-containing functions. With RSS(CH2)nSO2Na as the formulation of this broad class, five compounds each were propanesulfinates (n=3) and pentanesulfinates (n=5); R (n=3 or 5) was NaO2S(CH2)nS-,HO2C(CH2)2-, p-CH3C6H4-, C6H5- and NaO2S(CH2)nSS (CH2)4. These 10 compounds, with similar ones where n was 4 should afford a good basis for conclusions about structure-activity relations in this promising series. 1-Adamantyl and 9-fluorenyl p-toluenesulfinates were submitted as models for crystalline esters which are desired of sulfinates like the foregoing. A disulfide-sulfinate of the structure R superscript 1 SS(CH2)2S(O)R superscript 2 was submitted to determine whether sulfoxide functions can be desirable substitutes for sulfinate functions in exercising the postulated neighboring-group effect on -S sub n- functions in the same molecule. Studies in process are described in efforts to develop unsaturated counterparts of active agents as well as counterparts containing aromatic rings and a promising aminoalkyl type of R group.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1986
- Accession Number
- ADB109523
Entities
People
- Colin A. Lee
- J. D. Macke
- L. Field
- P. K. Singh
- Rohan Chandra
Organizations
- Vanderbilt University