Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies

Abstract

SRI International and Utah State University are developing methodology to assess the effectiveness of antiviral drug-monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pichinde virus surface antigens will be prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates screened for antiviral activity both in vitro and in animal model systems. Keywords: Antiviral agents; Antibodies; Clones; Chemotherapy.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1987
Accession Number
ADB110977

Entities

People

  • Bill B. Barnett
  • Marcia I. Dawson
  • Robert W. Sidwell

Organizations

  • SRI International

Tags

DTIC Thesaurus Topics

  • Anhydrides
  • Antigens
  • Cells
  • Chemistry
  • Culture Media
  • Health Services
  • Medical Personnel
  • Rodents

Readers

  • Oncology (Cancer Research).
  • Virology (or Medical Virology).