Preformulation and Formulation of Investigational New Drugs

Abstract

This annual report contains preformulation and formulation studies on WR249,655.2C(HI-6.2C1), WR238,605, WR171,669.HC1 (Halofantrine HC1), WR249,943. 2C1 (MMB-4.2CL), WR142,490.HC1 (MEFLOQUINE CH1) and Pyridostigmine Bromide. These studies include stability studies on WR249,655.2CL and WR249,943.2C1; physicochemical characterization of WR238,605; investigation of solid-state properties of various lots of WR171,669.HCL and WR142,490.HCL; initial development studies for a sustained release pyridostigmine bromide tablet. Keywords: Oximes; Antioxidents; Antidotes.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1985
Accession Number
ADB113186

Entities

People

  • Douglas R. Flanagan
  • John L. Lach
  • Lloyd E. Matheson Jr.

Organizations

  • University of Iowa

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetic Acid
  • Alcohols
  • Aqueous Solutions
  • Biomedical Research
  • Chemical Properties
  • Citric Acid
  • Detectors
  • Diffraction
  • Dosage Forms
  • Infrared Spectra
  • Measurement
  • Particle Size
  • Scattering
  • Sodium Hydroxide
  • Ultraviolet Spectra
  • X Rays
  • X-Ray Diffraction

Readers

  • Economics
  • Neurotoxicology
  • Parasitology and Pharmacology of Malaria.