Multiple Animal Studies for Medical Chemical Defense Program in Soldier/ Patient Decontamination and Drug Development on Task 84-4: Tissue Distribution of Arsenic in the Rabbit Following Subcutaneous Administration of Lewisite with or without British Anti-Lewisite Therapy

Abstract

A task was performed to determine if multiple intramuscular injections of British Anti-Lewisite (BAL; or 2,3-dimercapto-1-propanol) administered to rabbits at a non-toxic dosage afforded therapeutic benefits following a challenge dose of Lewisite (L), with particular emphasis on determining if BAL mobilized arsenic (As) for accumulation in neural tissues. BAL significantly reduced concentrations of AS in blood, brain, spinal cord, lung, liver, testes, and kidneys. Arsenic accumulated in brain and spinal cord tissues in rabbits not receiving BAL therapy whereas, BAL therapy reduced As concentration in these tissues to near the vehicle control level. Keywords: Lewisite (L), CSM, Antidotes, Arsenic.

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Document Details

Document Type
Technical Report
Publication Date
Jun 15, 1987
Accession Number
ADB117112

Entities

People

  • Gerald L. Fisher
  • H. H. Harroff Jr.
  • Ronald L. Joiner
  • Thomas H. Snider
  • W. B. Keys Jr.

Organizations

  • Battelle Memorial Institute

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  • Biomedical

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  • Analysis Of Variance
  • Biomedical Research
  • Composite Materials
  • Connective Tissue
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  • Factor Analysis
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  • Sodium Compounds
  • Statistical Algorithms

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  • Environmental Engineering.
  • Neuroscience
  • Toxicology/Environmental Toxicology