Rare 2-Substituted Purine Nucleosides

Abstract

This project is concerned with the synthesis of rare 2-substituted purine nucleosides with therapeutic potential against RNA viruses. In the second year of the contract, eleven rate 2-substituted purine nucleosides were synthesized, purified, fully characterized, and submitted to the Department of Antiviral Studies. Antiviral screening data have been received on a few of the compounds submitted and there are some very interesting and positive results. One compound (2-acetonylinosine, AVS-002159) has been found to have very high activity against the SF virus. Another compound (2-vinylinosine, AVS-002716) has been found to have broad spectrum activity against a number of RNA viruses. Two other compounds (AVS-002883 and AVS-002884) have shown some activity against the RVF virus, and still another (AVS-002352) has shown activity against the YF virus. Five publications have appeared in 1987 on this work. Keywords: Rift Valley Fever virus; Yellow fever virus; Nucleoside, Synthesis(Chemistry).

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Document Details

Document Type
Technical Report
Publication Date
Oct 17, 1987
Accession Number
ADB119120

Entities

People

  • Vasu Nair

Organizations

  • University of Iowa

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Antiviral Agents
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Contracts
  • Liquid Chromatography
  • Molecules
  • Nucleosides
  • Organic Chemistry
  • Rna Viruses
  • Security
  • Spectra
  • Students
  • Viruses

Readers

  • Organic Chemistry
  • Virology (or Medical Virology).