Multiple Animal Studies for Medical Chemical Defense Program in Soldier/ Patient Decontamination and Drug Development on Task Order 84-6: Pyruvate Dehydrogenase System for Determining the Effectiveness of Arsenic Antidotes

Abstract

An in vitro method for screening arsenic antidotes was developed. This assay uses the inhibition of PDH (Pyruvate dehydrogenase) complex as its basis for quantitation. The assay is effective, inexpensive, and quantitative for comparing the efficacy of reactivators of PDH complex inhibitors which contain Arsenic(3+). The assay may also be of value in comparing the efficacy of chelating agents for arsenicals containing Arsenic(5+) and other inhibitors of sulfhydryl-containing enzymes, such as mercury, cadmium, and lead. Keyword: Lewisite.

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Document Details

Document Type
Technical Report
Publication Date
Mar 11, 1988
Accession Number
ADB120625

Entities

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  • David W. Hobson
  • Ronald L. Joiner

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  • Battelle Memorial Institute

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  • Biomedical

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  • Arsenicals
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