Design, Synthesis and Study of Biomimetic Catalysts.
Abstract
Biomimetic catalysts modelled after the alkaline phosphatases and acid phosphatases were synthesized, and their catalysis of the hydrolysis of phosphate triesters was studied. The compounds fall into three classes: those that bind one divalent M2+-ion; those that bind two M2+ - ions; and those that contain an imidazole with a pendant guanidinium ion. The syntheses of the compounds in the former two classes is described along with the summary of in vitro assays. the Zn2+ and Co2+-chelates of these are respectable catalysts for hydrolysis of triesters. The guanidinium imidazoles are ineffective catalysts. Keywords: Biomimetic, Catalyst, Organophosphate ester, Alkaline phosphatase, Acid phosphatase, Chelates.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1987
- Accession Number
- ADB120959
Entities
People
- Robert S. Brown
Organizations
- University of Alberta