Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies

Abstract

SRI International and Utah State University are developing methodology to assess the effectiveness of antiviral drug-monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pichinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates will be screened for antiviral activity both in vitro and in animal model systems. Keywords: Binding sites, Antiviral agents, Monoclonal antibodies.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1988
Accession Number
ADB123568

Entities

People

  • Bill B. Barnett
  • Marcia I. Dawson
  • Robert W. Sidwell

Organizations

  • SRI International

Tags

DTIC Thesaurus Topics

  • Anhydrides
  • Antigens
  • Azo Compounds
  • Biomedical And Dental Materials
  • Blood
  • Cell Line
  • Cells
  • Culture Techniques
  • Cultured Cells
  • Epithelial Cells
  • Health Services
  • Medical Personnel
  • Polymeric Films
  • Proteins
  • Rodents

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Virology (or Medical Virology).