Synthesis of Nucleoside Mono- and Dialdehydes as Antiviral Agents
Abstract
Two compounds, 4', 5'-unsaturated adenosine-2', 3'-dialdehyde and tubercidin-2', 3'-dialdehyde were submitted during the reporting period. Work on the synthesis of adenosine-2'-monoaldehyde, adenosine-3'-monoaldehyde and 5'deoxyadenosine-2', 3'-dialdehyde is still in progress. As a group the nucleoside dialdehydes thus far submitted have shown broad spectrum activity against many of the viruses in the screening system, and some, like guanosine dialdehyde, have shown remarkably low cytotoxicity. Even dialdehydes that cannot become phosphorylated, which is required for the antiviral activity of all clinically used nucleoside antivirals, showed antiviral activity. For example 5'-fluoro-5'-deoxyadenosine-2', 3'-dialdehyde showed good activity against yellow fever and 4', 5'-unsaturated adenosine-2', 3'-dialdehyde showed excellent activity against vesicular stomatitis virus. Keywords: Antiviral agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 15, 1987
- Accession Number
- ADB124358
Entities
People
- John P. Neenan
Organizations
- Rochester Institute of Technology