Drug Development Against Parasitic Diseases: Synthesis of the Antimalarial Agent Qinghaosu and Analogs.

Abstract

A stereoselective total synthesis of (+)-artemisinin has been improved from 18 steps to 13 steps with a resultant 12-fold increase in the overall yield. A new class of tricyclic analogs of artemisinin has been discovered that possess good in vitro antimalarial activity. U.S. and foreign patents have been filed. One paper has been published and three others are in preparation. Keywords: Qinghaosu. (AW

Document Details

Document Type
Technical Report
Publication Date
Jan 15, 1988
Accession Number
ADB125245

Entities

People

  • Mitchell A. Avery

Organizations

  • SRI International

Tags

DTIC Thesaurus Topics

  • Antimalarials
  • Arthropod Borne Diseases
  • Bacterial Infections And Mycoses
  • Diseases And Disorders
  • Infectious Diseases
  • Malaria
  • Mosquito Borne Diseases
  • Parasitic Diseases
  • Peroxides
  • Protozoan Infections

Fields of Study

  • Chemistry

Readers

  • Parasitology and Pharmacology of Malaria.
  • Systems Analysis and Design