Clinical Pharmacology Studies. Phase 1.

Abstract

The scientific work of this year centered around (1) The pharmacokinetics and pharmacodynamics of a low dose eight-hour intravenous infusion of pyridostigmine and (2) The bioava, safety, tolerance, pharmacokinetics and pharmacodynamics of two sustained release formulations of pyridostigmine compared to pyridostigmine syrup. The clinical portion of these two studies were designed in the second year under the provisions of Task Order 6. These protocols have been approved by the Johns Hopkins institutional review board and submitted for review by the Human Subjects Research Review Board. We anticipate that they will be initiated early in the third year of the contract. (kt)

Document Details

Document Type
Technical Report
Publication Date
Oct 17, 1988
Accession Number
ADB130072

Entities

People

  • Brent G. Petty
  • David M. Kornhauser
  • Paul S. Lietman

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Contract Administration
  • Contracts
  • Infusions
  • Institutional Review Board
  • Metabolism Phenomena
  • Pharmacokinetics
  • Pharmacology

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Toxicology/Environmental Toxicology