Rare 2-Substituted Purine Nucleosides

Abstract

This project was concerned with the synthesis of rare 2-substituted purine nucleosides with therapeutic potential against RNA viruses. A total of twenty-two rare 2-substituted purine nucleosides were synthesized, purified, characterized, and submitted to the Department of Antiviral Studies. Antiviral screening data received to data show some very interesting and positive results. One compound (2-acetonyinosine, AVS-002159) has been found to have very high activity (TI > 1000) against the Sandfly Fever Virus (Phlebovirus). Another compound (2-vinylinosine, AVS-002716) has been found to have low but broad spectrum activity against a number of RNA viruses. Two other compounds (AVS- 002883 and AVS-002884) have shown some activity against the Rift Valley Fever Virus, and still another (AVS-002352) has shown some activity against the Yellow Fever virus. 2-formyinosine (AVS-002352) has shown some activity against Type 2 Adenovirus and 2-hydroxymethylinosine (AVS-004232) has shown activity against the Vaccinia Virus. Ten publications have arisen directly from this work. Keywords: Chemical compositions.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1989
Accession Number
ADB132700

Entities

People

  • Vasu Nair

Organizations

  • University of Iowa

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Alkenes
  • Antiviral Agents
  • Chemical Synthesis
  • Chemistry
  • Liquid Chromatography
  • Nucleosides
  • Organic Chemistry
  • Rna Viruses
  • Spectra
  • Viruses

Fields of Study

  • Biology

Readers

  • Materials Science and Engineering.
  • Technical Research and Report Writing.
  • Virology (or Medical Virology).