Interferon Inducers against Infectious Diseases

Abstract

We have been able to formulate effective IFN inducers without CMC. Most of these inducers are less toxic than is ICLC, and some are about as toxic as IC itself. Therefore, the other components are essentially non-toxic. Preliminary data showed that one formulation may be less toxic than is IC. All but one of the formulations so far tested for immunogenicity have given negative results; the one exception is to be examined further. We have a number of formulation which are effective IFN inducers, and some which are effective against Rift Valley Fever virus in mice. Some show both activities. Keywords: RA1; Interferon; Antiviral agents; Poly ICLC; Carboxymethyl saccharides.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1989
Accession Number
ADB134571

Entities

People

  • Jake Bello
  • Judith O'malley

Organizations

  • Roswell Park Comprehensive Cancer Center

Tags

DTIC Thesaurus Topics

  • Acids
  • Albumins
  • Alcohols
  • Antiviral Agents
  • Biomedical And Dental Materials
  • Blood
  • Blood Volume
  • Carbohydrates
  • Chemistry
  • Infectious Diseases
  • Light Scattering
  • Materials
  • Molecular Sieves
  • Polymeric Films
  • Polysaccharides
  • Proteins
  • Viruses

Readers

  • Analytical Chemistry
  • Virology (or Medical Virology).