Sulfur Mustard (SM) Lesions in Organ-Cultured Human Skin: Markers of Injury and Inflammatory Mediators

Abstract

In this research program, we are: (a) developing in vitro human skin model with which to assess the amount of injury produced by topically applied sulfur mustard (SM), and (b) identifying markers of cell death and early mediators of the inflammatory response produced by SM in human skin. This second Annual Report will cover our progress since our first Annual Report, i.e., from February 17, 1988 to February 16, 1989. The most promising measure of skin injury is our paranuclear vacuolization test. Keywords: Sulfur mustard; Human skin lesions; Histology & histochemistry; Inflammatory mediators; Organ culture; Viability of human skin at 4 C; Paranuclear vacuolization test for epidermal injury; Acid phosphatase; Trypsin-like enzymes; Deoxyribonuclease; Ribonuclease; Hydroxyproline; Leukotriene B4; Interleukin 1.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1989
Accession Number
ADB134651

Entities

People

  • Arthur M. Dannenberg Jr.

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Anti-Bacterial Agents
  • Biomedical And Dental Materials
  • Biomedical Research
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemical Warfare Agents
  • Dermatologic Agents
  • Electron Microscopy
  • Macrophages
  • Plastics
  • Polymeric Films
  • Public Health
  • Resins
  • Surgery
  • Thymocytes

Readers

  • Geochemistry
  • Immunology and Pathology
  • Molecular and Cellular Biochemistry