Enhancement of Antiviral Agents through the Use of Controlled-Release Technology
Abstract
The major objectives of this research program are to develop a programmed-release delivery system (microcapsule system) designed to enhance the immunogenic potential of an inactivated (killed) Japanese Encephalitis (JE) virus vaccine, allowing for immunization against this viral agent and, to develop controlled-release microcapsule delivery systems that will enhance the effects of the following immune modulators and antiviral agents: muramyl tripeptide (MTP), interferon (IFN), and poly(riboinosinic acid-ribocytidylic acid) POLY(I C). More specifically, we are involved in the development of biocompatible, biodegradable, controlled-release microcapsule formulations to release poly(I C), interferon (IFN), and JE vaccine at controlled rates after a single intramuscular or intravenous administration. We also plan to develop microcapsule formulations that will target the release of MTP to macrophages, causing macrophage activation and subsequent nonimmune protection against active viral infections. During this year of the research program, we performed immunization studies with a prototype JE microcapsule formulation. The results obtained to date indicate the anti-JE antibody is present in the animals 136 days after administration of the prototype microcapsule formulation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 11, 1988
- Accession Number
- ADB142021
Entities
People
- Melinda G Hollingshead
- Richard M. Gilley
- Thomas R. Tice
- William M. Shannon
Organizations
- Southern Research