Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs Treatment and Prophylaxis.
Abstract
During the current reporting period this program was directed at the preparation of improved antileishmanial drugs based on the identification of two metabolites of the highly-active antileishmanial drug 8-(6-diethylaminohexylamino)-6-methoxy-4-methlquinoline, WR 6026. Ten compounds were synthesized and limited test data against visceral leishmaniasis in the hamster is reported. The first metabolite was the 4-hydroxymethyl derivative of WR 6026. The second metabolite was the 8-(6-ethylaminohexyl)amino derivative of WR 6026. Ten analogs of these metabolites of WR 6026 were prepared during the reporting period. Keywords: Antileishmanials, Metabolites, Diethylaminohexylamino methylquinoline. (JES)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1989
- Accession Number
- ADB144742
Entities
People
- A. B. Ash
- A. Markovac
- C. L. Stevens
- D. J. Dagli